产品货号：
GS4385
中文名称：
重组人FGF-7/KGF-1
英文名称：
Recombinant Human Keratinocyte Growth Factor-1/FGF-7
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 18.9kDa,a single,non-glycosylated polypeptide chain containing 163 amino acids.
储存条件：冷冻（-20℃）
概述
Human KGF-1 also known as Fibroblast growth factor 7(FGF-7),is encoded by the FGF7 gene.KGF-1 only binds to the b splice form of the tyrosine kinase receptor,FGFR2b/KGFR.Affinity between KGF-1 and its receptor can be increased by heparin or heparin sulfate proteoglycan.FGF-10,also called keratinocyte growth factor 2(KGF-2),shares 51%amino acid sequence identity and similar function to KGF-1,but uses an additional receptor,FGFR2c.KGF-1 plays an important role in the regulation of embryonic development,cell proliferation and cell differentiation.KGF-1 actives on keratinocytes,and exhibits mitogenic activity for epidermal cells,but essentially no activity for fibroblasts.KGF-1 has species crossactive,human KGF-1 shares 96%and 92%amino acid sequence identity with murine and rat FGF-7,respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人FGF-7/KGF-1，FGF-7/KGF-1, Human
储存条件：冷冻（-20℃）
概述
Human KGF-1 also known as Fibroblast growth factor 7(FGF-7),is encoded by the FGF7 gene.KGF-1 only binds to the b splice form of the tyrosine kinase receptor,FGFR2b/KGFR.Affinity between KGF-1 and its receptor can be increased by heparin or heparin sulfate proteoglycan.FGF-10,also called keratinocyte growth factor 2(KGF-2),shares 51%amino acid sequence identity and similar function to KGF-1,but uses an additional receptor,FGFR2c.KGF-1 plays an important role in the regulation of embryonic development,cell proliferation and cell differentiation.KGF-1 actives on keratinocytes,and exhibits mitogenic activity for epidermal cells,but essentially no activity for fibroblasts.KGF-1 has species crossactive,human KGF-1 shares 96%and 92%amino acid sequence identity with murine and rat FGF-7,respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞96%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 10ng/ml,corresponding to a specific activity of>1.0×105 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered solution in 20mMPB,0.5MNaCl,pH 8.0. |
| 内毒素 | Less than 1 EU/μg of rHuKGF-1/FGF-7 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | CNDMTPEQMA TNVNCSSPER HTRSYDYMEG GDIRVRRLFC RTQWYLRIDK RGKVKGTQEM KNNYNIMEIR TVAVGIVAIK GVESEFYLAM NKEGKLYAKK ECNEDCNFKE LILENHYNTY ASAKWTHNGG EMFVALNQKG IPVRGKKTKK EQKTAHFLPM AIT |
相关搜索：重组人FGF-7/KGF-1，FGF-7/KGF-1, Human